Tricyclohexyltin phenolates and the preparation thereof

ABSTRACT

WHEREIN R is cyclohexyl and Y1 5 are the same or different and Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen. This invention also comprises methods of preparing said novel compounds. This invention also comprises pesticidal compositions containing as active components said novel compounds.   This invention comprises novel tricyclohexyltin compounds of the formula

United States Patent inventors Bernard G. Kushlefsky Edison, N..1.; Wendall K. Whitney, Midland, Mich. Appl. No. 749,625 Filed Aug. 2, 1968 Patented Sept. 28, 1971 Assignees M & T Chemicals Inc.

Greenwich, Conn. by said Kushlefsky; The Dow Chemical Company Midland, Mich. by said Whitney TRICYCLOHEXYLTIN PHENOLATES AND THE PREPARATION THEREOF 18 Claims, No Drawings U.S. C1 260/429.7, 424/288 Int. Cl C07f 7/22, A0 in 9/24 Field of Search 260/429.7

, [56] References Cited UNITED STATES PATENTS 3,03 8,877 6/1962 Harrington et a1 260/429.7 X 3,099,668 7/1963 Zweigle et a1 260/429.7 3,113,144 12/1963 Zweigle 260/429.7 3,129,236 4/1964 Weissenberger 260/429.7 3,400,201 9/1968 Mocotte 260/429.7 X 3,409,653 11/1968 Stamm 260/429.7

Primary ExaminerJames E. Poet Assistant Examiner-Werten F. W. Bellamy Attorney- Kenneth G. Wheeless TRICYCLOHEXYLTIN PHENOLATES AND THE PREPARATION THEREOF The present invention relates to new and useful organotin compounds, pesticidal compositions containing said compounds, and the use of these compounds as biological toxicants.

The invention comprises novel tricyclohexyltin compounds of the formula wherein R is cyclohexyl and Y,,,, are the same or difierent and Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen, such that not more than four Y substituents are hydrogen.

Examples of the foregoing compounds are:

tricyclohexyltin-4-nitrophenate tricyclohexyltin pentachlorophenate tricyclohexyltin-2,4,5-trichlorophenate tricyclohexyltin-4-chlorol -cyclopentyl phenate tricyclohexyltin-Z,4-dichlorophenate tricyclohexyltin-4-cyanophenate tricyclohexyltinA-methylmercaptophenate tricyclohexyltin-o-phenylphenate The tricyclohexyltin substituted phenolates which have been unknown until now are obtained by reacting as reactants tricyclohexyltin hydroxide and a substituted phenol in a solvent capable of azeotroping water. The reaction mass thus formed is heated until all of the water byproduct is volatized, The product thus formed is then isolated and purified by conventional means.

This invention comprises a method of forming novel compounds of the formula wherein R is cyclohexyl, Y are the same or different and Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen, comprising reacting as reactants in the presence of a solvent capable of azeotroping water tricyclohexyltin hydroxide and a phenolic compound of the formula HO Ya E1. YL W.

wherein Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen, heating said reaction mixture and separating said novel compounds.

Typical examples of substituted phenols which can be reacted with tricyclohexyltin include p-nitrophenol, 2,4,5- trichlorophenol, 4-chloro-2cyclopentylphenol, 2,4- dichlorophenol, p-cyano-phenol, p-methylmercaptophenol, and o-phenylphenol.

In accordance with another of its aspects, this invention comprises a method for preparing tricyclohexyltin compounds of the formula comprising reacting a cyclohexyl magnesium halide (C H M SnMgX and tin tetrahalide SnX. in molar ratio of 3:1 wherein X is an active halide selected from the group consisting of chloride and bromide comprises maintaining a reaction mixture containing SnX, in excess of (C H QMgX, simultaneously adding to said reaction mixture (C H QMgX and the remainder of SnX, in molar ratio of 3: l agitating said reaction mixture during said addition whereby said reaction mixture is maintained substantially uniform, and adding to said reaction mixture the remainder of said (C H JMgX thereby forming (C.,H,,)SnX, reacting as reactants said (C H ),SnX and a substituted compound of the formula Na0 a r Y My! wherein Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen, heating said reaction mixture and separating said tricyclohexyltin compounds.

The tricyclohexyltin compounds of the formula wherein R is cyclohexyl and Y 5 are the same or different and Y is selected from the group consisting of alkyl, aryl, cycloal kyl, halogen, nitro, mercapto, cyano, and hydrogen, such that not more than four Y substituents are hydrogen formed in the practice of this invention include products wherein the cyclohexyl group herein designated C ll is inertly substituted.

Typical products formed by the process include: tri(2-methylcyclohexyl) tin substituted phenate tri(Z-butylcyclohexyl) tin substituted phenate tri(Z-phenylcyclohexyl) tin substituted phenate tri(3,3,S-trimethylcyclohexyl) tin substituted phenate tri(3,5-dimethylcyclohexyl) tin substituted phenate tri(4-t-butylcyclohexyl tin substituted phenate tri(2-isopropyl-5-methylcyclohexyl) tin substituted phenate tri(2,S-dimethylcyclohexyl) tin substituted phenate tri(3,4-dimethylcyclohexyl) tin substituted phenate The tin tetrahalide which may be used in practice of this invention may be SnX, wherein X may be an active halide selected from the group consisting of chloride and bromide. Preferably, SnX may be tin tetrachloride, SnCl The Grignard reagent which may be used in practice of this invention, preferably cyclohexyl magnesium chloride (and including Grignard reagents containing inertly substituted cyclohexyl radicals as noted supra), may be prepared by the reaction of a cyclohalide with magnesium according to the following reaction: (C H,,)X+Mg-.- (C H )MgX This reaction may preferably by carried out under an inert atmosphere, e.g. nitrogen gas, in the presence of an aliphatic ether such as diethyl ether, din-butyl ether, etc., or in the presence of a compound Q as hereinafter described. Various initiators may be present to facilitate formation of the Grignard reagent.

The compound Q, as this expression is used herein for the purpose of brevity, includes cyclic ethers containing S6 members in the ring with at least one hydrogen atom attached to each carbon atom in the ring and having the formula:

wherein X is a methylene group or an N-alkyl group; R" is an unsubstituted saturated divalent aliphatic hydrocarbon radical; R is an ethylene radical, an ethylenically unsaturated divalent hydrocarbon radical, a methylene radical, OT E CHR' (R"' being hydrogen or an aliphatic radical); and O is oxygen. When X is N-alkyl, the ring shall contain 6 members with X and in a position 114 with respect to each other.

Compounds within this definition include tetrahydrofuran, tetrahydropyran, Z-methyltetrahydrofuran, 2-etho'xytetrahydropyran, tetrahydrofurfuryl ethyl ether, dihydropyran, and N-methylmorpholine. The compound Q may bear as substituent inert groups, i.e. groups which are not reactive with organomagnesium halides, or with any of the components and products of the reaction mixtures of the present process. illustrative inert substituents may include substituted and unsubstituted alkyl, aryl, alkoxy, and aryloxy groups (including those bearing substituents thereon which are unreactive to other components of the reaction mixture as herein specified). Where nitrogen replaces a carbon atom in the ring at X, the nitrogen atom must be substituted with a group, such as an alkyl group, which is unreactive to the reactants or reaction products.

It is a characteristic of compound O that the oxygen is available for electron donation, i.e. the free Ir-electrons present on the oxygen are available for coordination with the Grignard reagent. Any large blocking groups on the carbon atoms adjacent to the ring oxygen may impair the availability of these electrons and the reactivity of the compound for forming a complex and assisting in the reaction. In addition to the compounds listed above as being suitable for compound Q, other equivalent compounds satisfying the requirements for this complexing agent and solvent will be apparent to those skilled in the art from the present specification. Since compound 0 may also function as a solvent, a compound O which has a high melting point may be used in practice of this invention, but if it is used as solvent, the high melting point (e.g. above 90 C.) may cause difficulty in carrying out the reaction. The Grignard reagent formed by the process of, e.g. reaction (4) supra'may be preferably in the form of a solution of its complex with the ether or the compound Q, e.g. as a solution of (C,H,,)MgX-Q in O. For purposes of convenience, the equations herein are written without reference to the ether or compound 0 which may be present.

in practice of the process of this invention, the reaction between the tin tetrahalide SnX and the Grignard reagent (C HMMgX may be: 3(C H )MgX-l-SnX -2(C H,,) SnX 'BMgX, This reaction may be carried out by adding to a reaction vessel [-100 mole percent, preferably 10-40 mole percent, say 25 mole percent of the SnX, to be used in the reaction. Preferably, this may also be added with appropriate solvent, typically a hydrocarbon having a boiling point of 30 C.-l50 C. say about 137 C., including, e.,g. toluene, heptane, cyclohexane, etc. The hydrocarbon may be xylene which may be added to the SnX. in amount of 10-20 moles, say moles, per mole of SnX to be consumed during the reaction. The tin tetrahalide SnX, and the solvent may be added to the reaction vessel in the form of a solution of tin tetrahalide.

To the preferably well-agitated reaction mixture containing SnX, in excess of (C HMMgX, and preferably containing none of the latter, there may be simultaneously added the remainder of the SnX., i.e. 0-99 mole percent, preferably 60-90 mole percent, say 75 mole percent of the SnX used in the reaction, together with all the Grignard reagent (C H )M gX.

In the preferred embodiment, the rates of addition of the added (C HMMgX and the SnX, during addition may be preferably maintained at 3 moles of (C H,,)MgX per mole of SnX.. Control of the ratio during addition at the stated equivalent level of preferably 3:1 may be effected by controlling the flow of each of the reactants. The unusual results attained by the process of this invention may particularly result at least in part from the technique of controlling the ratio of rates of addition of the added materials so that it falls within this ratio of about 310.321. Thus the reaction medi u m at a given time may be considered as having been formed by mixing the reactants in equivalent, i.e. 3:1 molar proportion. preferably in the presence of an excess of SnX, corresponding to that which was present, if any, in the reaction vessel at the beginning of the reaction. The high degree of agitation preferably maintained in the reaction mixture insures that the reaction mixture is maintained uniform, i.e. that at no place in the reaction mixture is there any localized substantial excess of (C H,,)MgX.

Preferably, the exothermic reaction mixture may be maintained at 25 C.-95 C., preferably less than C., say at 72 C. Reaction may, if desired, be carried out at 30 C.40 C. Typically, the (C H, )MgX and SnX, may be added to the reaction mixture over 60-210 minutes, say 120 minutes.

The remainder of the (C H JMgX, typically 5-100 mole percent, say 25 mole percent, may then be added to the reaction mixture over 15-60 minutes, say 30 minutes. Preferably the reaction mixture may during this addition be maintained at gentle reflux temperature, typically 75 C. C. when the refluxing liquid includes, e.g. xylene-tetrahydrofuran, for 30-240 minutes, say minutes.

The reaction mixture may then be hydrolyzed to liberate (C H,,)SnX. Typically this may be effected by diluting the mixture at 30 C.-40 C. say 30 C. with water, preferably containing electrolyte such as sulfuric acid in the amount of l%-1510% by weight. Typically hydrolysis may be effected in two steps by mixing the reaction mixture in a first step with 300-400, say 325 parts by weight of water per mole of SnX, utilized which amount of water may be sufficient to form the hexahydrate MgX '6H O and an organic layer. The organic layer may be separated and in a second step the hexahydrate dissolved in -500, say 300 parts of water, to which may be thereafter added electrolyte, say 150-300, say 250 parts of 10% sulfuric acid. The mixture may be agitated and the organic layer drawn off and combined with the earlierobtained organic layer.

The novel compounds are useful as pesticides, e.g. as plant protecting agents, miticides, and insecticides. For these purposes they can be converted to emulsions, solutions, or mixed with fillers in a conventional manner.

EXAMPLE 1 Preparation of Tricyclohexyltin-4-nitrophenate ANALYSIS Percentage Theory Found EXAMPLE 2 Preparation of Tricyclohexyltin Pentachlorophenate 96.3 grams (0.25 mole) of tricyclohexyltin hydroxide and 66.6 grams (0.25 mole) of pentachlorophenol were added to 500 milliliters of benzene. The procedure of example 1 was followed, including the maintenance of a nitrogen atmosphere at all times. The purified product exhibited a melting point range of 106.5 C.-ll0.5 C. and a weight of 152.0 grams (theoretical 158.4 grams).

Preparation ofTricyclohexyltin-2,4,5-trichlorophenate 96.3 grams of (0.25 mole) of tricyclohexyltin hydroxide and 49.36 grams of 2,4,5-trichlorophenol were added to 500 milliliters of benzene in a 1-liter flask. The procedure of example 1 was followed, including the continuous maintenance of a nitrogen atmosphere. The product, tricyclohexyltin-2,4,5- trichlorophenate exhibited a weight of 107 grams (theoretical 141.15 grams).

ANALYSlS Percentage Theory Found Tin 21.02 21.00%

Chlorine 18.87: 16.5%

EXAMPLE 4 Preparation of Tricyclohexyltin 4-chloro-2-cyclopentyl Phenate ANALYSIS Percentage Theory Found Tin 20.75% 20.97%

Chlorine 6.2; 5.79%

EXAMPLE 5 Preparation of Tricyclohexyltin 2,4-dichlorophenate 96.3 grams (0.25 mole) of tricyclohexyltin and 40.75 grams (0.25 mole) of 2,4-dichlorophenol were added to 500 milliliters of benzene in a l-liter flask. The procedure of example 1 was followed to obtain a purified tricyclohexyltin 2,4- dichlorophenate product exhibiting a weight of 114.5 grams (theoretical 1325 grams) which was a 88.2% yield. The melting point range was 43 C.-45 C.

ANALYSlS Percentage Theory Found Tin 22.39% 22.62%

Chlorine 13.389: 12.51%

EXAMPLE 6 Preparation of Tricyclohexyltin 4-cyanophenate 96.3 grams (0.25 mole) of tricyclohexyltin hydroxide and 29.78 grams 0.25 mole) of 4-cyanophenol were added to 500 milliliters of benzene in a l-liter flask. The procedure of example l was followed to obtain a tricyclohexyltin 4- cyanophenate product exhibiting a weight of 107.3 grams (theoretical 121.6 grams) which was a 88.2% yield. The melting point range was C.-10 1 .0 C.

ANALYSIS Percentage Theory Found Tin 24.1 1% 24.26% Nitrogen 2.88% 2.84%

EXAMPLE 7 Preparation of Tricyclohexyltin 4-methylmercaptophenate 96.3 grams (0.25 mole) of tricyclohexyltin hydroxide and 35.05 grams (0.25 mole) of 4-methylmercaptophenol were added to 500 milliliters of benzene in a 1-liter flask. The procedure of example 1 was followed to obtain tricyclohexyltin 4-methylmercaptophenate liquid product exhibiting a weight of 120.00 grams (theoretical 126.8 grams) which was a 93.9% yield.

ANALYSIS Percentage Theory Found Tin 23.4% 13.63% Sulfur 6.327 6.2891

EXAMPLE 8 Preparation of Tricyclohexyltin-o-phenylphenate 96.3 grams (0.25 mole) of tricyclohexyltin hydroxide and 42.55 grams (0.25 of o-phenylphenol were added to 500 milliliters of benzene. The procedure of example 1 was followed to obtain a tricyclohexyltin-o-phenylphenate product exhibiting a weight of grams (theoretical 134.3 grams) which was a yield of 96.8% of theoretical. The melting point range was 75.5 C.-77.0 C. The percentage tin was found to be 22.31% (theoretical 22.09%)

The novel compounds of the foregoing examples can be applied to soil or plants, including particularly soil by a variety of means. One of the aspects of this invention is the formulation of compositions such as to permit a uniform predetermined application of the novel compounds to an environment to produce the desired effect. Compositions to be applied to soil or plants include liquid extending agents such as solvent or diluents within which the novel active compounds of this invention are dissolved or suspended; wetting or emulsifying agents which serve in providing uniform dispersions of the solution of the active ingredient in the extending agent and adhesive agent or spreading agent which improves the contact of the novel compounds of this invention with soil and plant surfaces or other surfaces to be protected. Therefore, most compositions for applications usually include an extending agent and a wetting or emulsifying agent.

The novel compounds of this invention need not be dissolved in the extending agent. but may be merely dispersed or suspended in the extending agent as a suspension or emulsion. The novel compounds of this invention may first be dissolved in a suitable organic solvent and the organic solution of the active ingredient then incorporated in water or in an aqueous extending agent in the form of a heterogeneous dispersion. Examples of some suitable organic solvent for use as extending agent includes hexane, benzene, toluene, acetone, cyclohexanone, methyl ethyl ketone, isopropanol, butanediol, methanol, diacetone alcohol, xylene, dioxane, isopropyl ether, ethylene dichloride, tetrachloroethane, hydrogenated naphthalene, solvent naphtha, petroleum fractions, such as kerosene, and the like.

Solid extending agents in the form of particulate solids are very useful in the practice of the present invention. in using this type of extending agent, the active ingredient is either adsorbed or dispersed on or in a finely divided solid material. Preferably, the solid extending agents are not hygroscopic, but are materials which render the compositions permanently dry and free-flowing. Suitable solid extending agents include the natural clays such as china clays, the bentonites, and attapulgites; other minerals such as talc, pyrophyllite, quartz, diatomaceous earth, fullers earth, chalk, rock phosphate, kaolin, kieselguhr, volcanic ash, salt; chemically modified minerals such as, acid-washed bentonite, precipitated calcium phosphate, calcium carbonate, calcined magnesium, colloidal silica; and other solid materials such as powdered cork, powdered wood, and powdered pecan or walnut shells. These materials are used in finely divided form, of approximately a size range pasing through to 40 mesh or of a finer size. Particulate solid concentrated of compositions are applied to the soil by admixture at the time of application with a particulate solid carrier material.

if desired, the novel compounds of this invention can be applied in a wettable powder using a liquid carrier material. When used by this method, a wetting agent or surface active agent is added to a concentrate composition to render the particulate solid extending agent wettable by water to obtain a stable aqueous dispersion or suspension suitable for use as a spray. Also the extending agent applied as a wettable powder is used in very finely divided form preferably in a size small as 100 mesh or smaller.

Surface active agents for wetting emulsifying or dispersing serve in providing uniform dispersion of the novel compounds of this invention of liquid and solid types may be either anionic or cationic, nonionic types, including mixtures thereof. Suitable surface active agents are the organic surface active agents capable of lowering the surface tension of water and include the conventional soaps, such as the water-soluble salts of longchain carboxylic acids; the amino soaps, such as the amine salts of long-chain earboxylic acids; the sulfonated animal, vegetable, mineral oils; quaternary salts of high molecular weight acids; rosin soaps, such as salts of abietic acid; sulfuric acid salts of high molecular weight organic compounds; algin soaps; ethylene oxide condensed with fatty acids, alkyl phenols and mercaptans; and other simple and polymeric compositions having both hydrophilic and hydrophobic functions.

Concentrated compositions containing the novel compounds of this invention should have the active novel compounds and the surface active agents present in higher concentrations than the toxicant compositions applied in the field so that upon dilution with a solid or liquid carrier resulting compositions will contain optimum proportions of the active novel compounds and surface active agent. The compositions should be such to obtain uniform distributions and to maintain the active novel compounds to promote rapid assimilation by plants.

The use of a surface active agent may be necessary in formulating liquid concentrate composition to obtain a constant composition of sufficient concentration of the novel compounds of this invention in a liquid extending agent. The liquid extending agent must be selected not only on the basis of the amount of the novel compound of this invention dissolved but also upon the basis of this solution and temperature of the total composition. Thus, in some formulations, a particular combination of solvents gives us sufficiently low solvent temperatures but the amount of the novel compound dissolved or dispersed in the mixture is insufficient and a suitable surface active agent must be selected such that the novel compound can be dispersed in the composition. Preferably a concentrate composition has a solution temperature below 0 C. although compositions having higher solution temperatures can be used.

The concentration of the novel compounds of this invention in a particulate solid or dust concentrate composition may vary over wide ranges depending upon the nature of the solid extending agent. it is to be noted that surface activated agents are not usually required in dust concentrate composition although they can be used if desired. if a dust concentrate composition is to be applied as a wettable powder, however, a surface active agent should be added to the concentrate composition. Ordinarily, the amount of surface activated agent will be in the amount of 0.1% 15% by weight of the composition.

The carrier material used for the uniform distribution of the novel compounds of this invention used as pesticide may be either liquid or particulate solid materials. The liquid and solid extending agents used to prepare concentrate compositions may also be used as the carrier. However, the use of the concentrate composition materials carrier may not be economical. Water is the preferred liquid carrier, both for use with the liquid concentrate compositions and wettable powder concentrate. Suitable particulate solid carriers include the particulate extending agents noted above as well as solid fertilizers, such as ammonium nitrate, urea, super phosphate, as well as other materials in which plant organisms may take root and grow such as compost, sand, and humus. Liquid and dust concentrate compositions containing the novel compound of this invention can also contain other addiaments such as fertilizer and pesticides. These addiaments may be used as. or in combination with the carrier materials.

Compositions containing the novel compounds of this invention may be applied to plants in a conventional manner. Thus, dust and liquid compositions may be applied to the foliage of growing plants by use of powdered-dusters, broom and hand Sprayers, and other spray dusters. Compositions containing the novel compounds of this invention can be applied from airplanes as dust.

EXAMPLE 9 TABLE I Concentration of Aqueous Solutions of the Novel Compounds for Controlling Two Spotted Spider Mites Concentration in Parts Per Million to Effectively Control Twu Spotted Spider M lies Compound of Example No.

in further tests, to determined quantities of water containing daphnia, rams horn snails, and goldfish were added sufficient quantities of the novel compounds to obtain a concentration of 0.4 to 2 parts per million, by weight, of the novel compounds of examples I through 8. A concentration of 2 parts per million of any of the novel compounds of this invention is sufi'icient to eradicate daphnia.

in still further tests, emulsion compositions containing 50 parts per million, by weight, of the compounds of examples 1 through 8, when applied by contact to house flies, American cockroaches, and confused flour beetles, completely eradicated more than 90% of those pests. Thus, coating compositions containing very small quantities of the novel compounds of this invention give a protective coating effective against house flies, American cockroaches and confused flour beetles.

For evaluation of the bacteristatic and fungistatic effects of the compounds, Staphylococcus aureus, Escherichia coli, Candida albicans, Trichophyton mentagrophytes, Bacillus subtilis, Aerobacter aerogenes, Aspergillus terreus, Candida pelliculosa, Pullularia pullulans and Salmonella typhosa were each tested. Each of the eight novel compounds was mixed in predetermined concentrations with hot sterile agar which was subsequently poured into Petri dishes, cooled, and allowed to harden. Nutrient agar containing the novel compounds was then inoculated with each of the aforementioned micro organisms and incubated for days at 27 C. The results of these tests are reported in table ll.

TABLE II Inoculant 1 2 3 4 5 6 7 8 Staphylococcus aureuan 100 10 10 100 10 500 500 10 Escherichia coli 500 500 500 Candida albicans 500 500 500 100 500 1G Trichophylon mentagroph Utes 500 10 10 10 10 500 500 10 Bacillus sublilia 500 10 10 10 10 500 500 10 Aerobacler aerogenes 500 500 500 500 Aspergillus terreua 100 160 100 100 100 500 500 100 Candida pelliculosa 500 500 100 500 500 100 Pullularia pullulans 100 100 100 100 100 500 Salmonella typhosa u 500 500 It is noted froma-an examination of the data in table II that the novel compounds of this invention are active bacteriostats and fungistats; that effective concentrations in some cases were as low as 10 parts per million of the test compounds. Usually these novel compounds will be applied as bacteriostats or fungistats at concentrations in the range of 0.000l%-.0% preferably 0.0l%0.0l%0.5% suspended, dispersed, or dissolved in inert carriers.

As many embodiments of this invention may be made without departing from the spirit and scope thereof, it is to be understood that the invention includes all such modifications as come within the scope of the appended claims.

1. Novel tricyclohexyltin compounds of the formula wherein R is cyclohexyl, Y are the same or different and Y is selected from the group consisting of alkyl, aryl, cycloalkyl,

halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen.

2. The compound of claim 1 which is tricyclohexyltin-4- nitrophenate.

3. The compound of claim 1 which is tricyclohexyltin pentachlorophenate.

4. The compound of claim 1 which is tricyclohexyltin-2,4,5-

trichlorophenate.

5. The compound of claim 1 which is tricyclohexyltin-4- wherein R is cyclohexyl, Y are the same or different and Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen comprising reacting as reactants in the presence of a solvent capable of azeotroping water tricyclohexyltin hydroxide and a phenolic compound of the formula HO Ya wherein Y is selected from the group consisting of alkyl, aryl, cycloalkyl, halogen, nitro, mercapto, cyano, and hydrogen such that not more than four Y substituents are hydrogen a heating said reaction mixture, and separating said novel compounds.

ll. The method of claim 10 wherein said compound is 4- nitrophenol.

12. The method of claim 10 wherein said compound is pentachlorophenol.

13. The method of claim 10 wherein said compound is 2,4,5-trichlorophenol.

14. The method of claim 10 wherein said compound is 4- chloro-2-cyclopentylphenol.

15. The method of claim 10 wherein said compound is 2,4- dichlorophenol.

16. The method of claim 10 wherein said compound is 4- cyanophenol.

17. The method of claim 10 wherein said compound is 4- methylmercaptophenol.

18. The method of claim 10 wherein said compound if 0- phenylphenol.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent: No. 3509 173 Dated 9/28/71 InVentm-(S) Bernard G. Kushlefsky and Wendell K. Whitney It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Abstract of the Disclosure: Following the word "formula" insert R3Sn"O 3 Column 1, lines 15 and M4, "Y should read --Y Column 1, line 64, 'W-chloro-Z cyclopentylphenol" should read +-chloro-2-cyclopentylphenol.

Column 2 line 11, "CC H )SnX" should read --(C H SnX--.

Column 2 line 32 "Y should read --Y Column 5, line 65, "88.2%" should read --86.

Claims 1 and 10 "Y should read --Y Signed and sealed this 9th day of May 1972.

(SEAL) Attest:

EDWARD M.F'LE1CHER, JR. ROBERT GOTTSCHALK Attesting Officer Co missioner of Patents DRM PO-105O (10-09) USCOMM-DC 60376-P69 U S GOVERNMENY HUNTING OFFiCE I969 0-365-334 

2. The compound of claim 1 which is tricyclohexyltin-4-nitrophenate.
 3. The compound of claim 1 which is tricyclohexyltin pentachlorophenate.
 4. The compound of claim 1 which is tricyclohexyltin-2,4,5-trichlorophenate.
 5. The compound of claim 1 which is tricyclohexyltin-4-chloro-2-cyclopentylphenate.
 6. The compound of claim 1 which is tricyclohexyltin-2,4-dichlorophenate.
 7. The compound of claim 1 which is tricyclohexyltin-4-cyanophenate.
 8. The compound of claim 1 which is tricyclohexyltin-4-methylmercaptophenate.
 9. The compound of claim 1 which is tricyclohexyltin-o-phenylphenate
 10. The method of forming novel compounds of the formula
 11. The method of claim 10 wherein said compound is 4-nitrophenol.
 12. The method of claim 10 wherein said compound is pentachlorophenol.
 13. The method of claim 10 wherein said compound is 2,4,5-trichlorophenol.
 14. The method of claim 10 wherein said compound is 4-chloro-2-cyclopentylphenol.
 15. The method of claim 10 wherein said compound is 2,4-dichlorophenol.
 16. The method of claim 10 wherein said compound is 4-cyanophenol.
 17. The method of claim 10 wherein said compound is 4-methylmercaptophenol.
 18. The method of claim 10 wherein said compound is o-phenylphenol. 